This study was carried out on a 4 year old local grape variety (Vitis vinifera) grown in Erciş district during the vegetation period of 2019. In this study, three different treatments (Sodyum bikarbonat, % 80 WP Kükürt and 50 g/l Triadimenol) were used for control of powdery mildew disease (Erysiphe necator Schwein), and some of the yield and quality criteria of Erciş grape cultivars and their effects on disease control were investigated. The experiment was carried out in the fields where viticulture is made in Erciş district of Van. Grapevine controls were carried out at 20-day intervals between May and September at different growth and development periods during the vegetation period starting from the grain attitude of the vineyards until the harvest. The grapevines were sprayed 3 times according to the program. The criteria such as number of clusters, weight of clusters, average yield, total chlorophyll density, amount of water soluble dry matter, pH, titratable acidity (%) were examined. As a result of the analyzes, the difference between the application groups of pH, SÇKM, TA (%) and yield values were found insignificant. In the study, the difference between disease severity according to the scale values of the application groups in both leaf and cluster was found to be statistically significant. In this contex, all treatments reduce the severity of the disease; it was determined that especially 80% WP Sulfur and Sodium bicarbonate was more effective than 50 g/l Triadimenol treatment. As a result, it is thought that sodium bicarbonate can be used as an alternative to fungicides.